Purpose of the PBT Profiler:

Identifying materials that may need additional technical evaluation for Persistence, Bioaccumulation and Toxicity characteristics.

1. The PBT Profiler is a predictive screening tool to be used when data are not available.       More information
2. For technical reasons, there are certain chemicals (or chemical classes) that should not be profiled with the PBT Profiler.       More information
3. The PBT Profiler is a screening tool, PBT estimations rendered by the PBT Profiler are not sufficient for definitive PBT determinations. The PBT Profiler is a research, not regulatory, tool to identify chemicals that may need further evaluation for potential Persistence, Bioaccumulation and Toxicity characteristics.       More information
4. EPA does not use the PBT Profiler to assess and identify new chemicals submitted as PreManufacture Notices (PMNs) under the Toxic Substances Control Act, as being in the New Chemicals Category for Persistent, Bioaccumulative, and Toxic Chemicals. Professional judgment of EPA OCSPP subject matter experts is used to assign PBT concern levels to PMNs. The PBT Profiler does contain the same computer models used by EPA to screen PMNs for P, B, and aquatic "T". However, to assign PBT concern levels to PMNs, human health T is determined by EPA OCSPP human health experts using nearest analog analysis and is based on chronic oral systemic toxicity to humans, mammals, and birds. Aquatic toxicity is not a driving factor for PBT "Toxicity" concern because food chain transport is the exposure route of concern for PBTs.

To continue using the PBT Profiler, please acknowledge that you have read and understand the issues and considerations discussed above:

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Developed by the Environmental Health Analysis Center under contract to the Office of Chemical Safety and Pollution Prevention , U.S. Environmental Protection Agency
Computer Resources Donated by SRC, Inc.          Ver 2.001     Last Updated September 28, 2016