The PBT Profiler is a predictive screening tool to be used when data are not
For technical reasons, there are certain chemicals
(or chemical classes) that should not be profiled with the PBT Profiler.
The PBT Profiler is a screening tool, PBT estimations rendered by the
PBT Profiler are not sufficient for definitive PBT determinations. The
PBT Profiler is a research, not regulatory, tool to identify chemicals
that may need further evaluation for potential Persistence,
Bioaccumulation and Toxicity characteristics.
EPA does not use the PBT Profiler to assess and identify new chemicals submitted as
PreManufacture Notices (PMNs) under the Toxic Substances Control Act, as being in the
New Chemicals Category for Persistent, Bioaccumulative, and Toxic Chemicals.
Professional judgment of EPA OCSPP subject matter experts is used to assign PBT
concern levels to PMNs. The PBT Profiler does contain the same computer models used
by EPA to screen PMNs for “P”, “B”, and aquatic "T". However, to assign PBT concern
levels to PMNs, human health “T” is determined by EPA OCSPP human health experts using
nearest analog analysis and is based on chronic oral systemic toxicity to humans,
mammals, and birds. Aquatic toxicity is not a driving factor for PBT "Toxicity"
concern because food chain transport is the exposure route of concern for PBTs.
To continue using the PBT Profiler, please acknowledge that you
have read and understand the issues and considerations discussed above:
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